Migraines linked to higher risk of dementia

Dementia is the most common neurological disease in older adults, whereas headaches, including migraines, are the most common neurological disorder across all ages. In a recent study in the International Journal of Geriatric Psychiatry that included 679 community-dwelling adults aged 65 years and older, migraines were a significant risk factor…

Molecule reduces accumulation of toxic protein in Parkinson’s disease model: The discovery supports GM1 ganglioside as a potential target for Parkinson’s therapy

Parkinson’s disease often begins with small tremors. Over time symptoms worsen. Tremors become shakes and stiffness takes the body hostage. People with advanced stages of the neurodegenerative disease often have trouble with coordination, walking and maintaining their balance. Currently no cure exists for the condition and available treatments only address…

Scientists map toxic proteins linked to Alzheimer’s

A team of researchers from McMaster University has mapped at atomic resolution a toxic protein linked to Alzheimer’s disease, allowing them to better understand what is happening deep within the brain during the earliest stages of the disease. The findings, published on the front cover of the current edition of…

Sleep history predicts late-life Alzheimer’s pathology: Findings suggest novel, sleep-based diagnosis and treatment methods

Sleep patterns can predict the accumulation of Alzheimer’s pathology proteins later in life, according to a new study of older men and women published in JNeurosci. These findings could lead to new sleep-based early diagnosis and prevention measures in the treatment of Alzheimer’s disease. Alzheimer’s disease is associated with disrupted…

Radio-tracking dolphins reveals intimate details about their behavior

Using telemetry units in hospitals to monitor patient health is standard practice. Now, a similar approach is proving to be invaluable for dolphins, too. Researchers from Florida Atlantic University’s Harbor Branch Oceanographic Institute, Hubbs-SeaWorld Research Institute and collaborators have conducted the most extensive radio-tracking effort of bottlenose dolphins in the…

A boundary dance of amyloid-beta stepping into dementia: Formation mechanism of the causative substances of Alzheimer’s disease revealed by molecular dynamics simulations and NMR experiments

Many proteins aggregate at higher concentrations and form spherical substances called oligomers and acicular substances called amyloid fibrils. These protein aggregates cause more than 30 kinds of diseases, for example, Alzheimer’s disease is thought to be caused by the oligomers and amyloid fibrils formed by aggregation of amyloid-β (Aβ) peptides….