Novel combination of drugs may overcome drug-resistant cancer cells

Cancer cells can adapt and develop resistance to chemotherapy drugs, making it difficult to eradicate tumors. A new study led by investigators from Brigham and Women’s Hospital suggests that a combination of three drugs, including a new class of glucose-6-phosphate dehydrogenase inhibitors, could overcome cross-therapy resistance. The results of the…

The brain consumes half of a child’s energy — and that could matter for weight gain: New paper proposes that variation in brain energy expenditure during childhood could be linked to obesity risk

Weight gain occurs when an individual’s energy intake exceeds their energy expenditure — in other words, when calories in exceed calories out. What is less well understood is the fact that, on average, nearly half of the body’s energy is used by the brain during early childhood. In a new…

Bone cells suppress cancer metastases

In breast cancer, there are cases of women and men whose cancer returns in their bones 20-30 years after they were treated for their primary disease and thought they were cancer-free. This phenomenon always puzzled Jefferson researcher Karen Bussard, PhD. How is it possible that breast cancer cells from a…

Tumor mutations may predict response to immunotherapy

Checkpoint inhibitor drugs that stimulate the immune system have become a growing success story in the treatment of some cancers. But about half of patients whose tumors are marked by a large number of mutations from so-called mismatch repair genetic deficiency fail to respond to the drugs. Now, researchers from…