Keeping livestock in the yard just might help your baby’s immune system: Amish babies’ gut microbes lead to more robust immune development in newborn pigs

Getting up close — and a little dirty — with farm animals just might help us fend off illness, say researchers who’ve further demonstrated the benefits of early exposure to a wide variety of environmental bacteria. Scientists from The Ohio State University found that bacteria and other microbes from rural…

An ‘EpiPen’ for spinal cord injuries

An injection of nanoparticles can prevent the body’s immune system from overreacting to trauma, potentially preventing some spinal cord injuries from resulting in paralysis. The approach was demonstrated in mice at the University of Michigan, with the nanoparticles enhancing healing by reprogramming the aggressive immune cells — call it an…

Mutation discovery leads to precise treatment for child with severe lymphatic disorder: A repurposed drug reshapes anatomy, brings dramatic clinical improvement

Faced with a preteen boy in pain and struggling to breathe from a severe, deteriorating rare condition, researchers at Children’s Hospital of Philadelphia identified the responsible gene mutation and harnessed that knowledge to develop a novel treatment that dramatically improved the problem. The patient had been born with a complex…

Lymphoma trial finds combination targeted therapy effective prior to chemotherapy: MD Anderson Phase II study suggests patients with lymphoma subtype may be able to avoid chemotherapy in the future

Results of a Phase II clinical trial conducted at The University of Texas MD Anderson Cancer Center revealed that combination targeted therapy, consisting of rituximab, lenalidomide and ibrutinib (RLI), had an 84.6 percent overall response rate (ORR) and 38.5 percent complete response rate (CRR) when given prior to any chemotherapy…

Tumor mutations may predict response to immunotherapy

Checkpoint inhibitor drugs that stimulate the immune system have become a growing success story in the treatment of some cancers. But about half of patients whose tumors are marked by a large number of mutations from so-called mismatch repair genetic deficiency fail to respond to the drugs. Now, researchers from…

Targeted lymphoma drug gets green light for NHS in England

People with a certain type of lymphoma will now have access to a targeted cancer drug on the NHS in England. Brentuximab vedotin (Adcetris) was approved by the National Institute for Health and Care Excellence (NICE) for some patients with a type of skin lymphoma, called CD30-positive cutaneous T-cell lymphomas…