Multiple myeloma: DNA rearrangement may predict poor outcomes

A certain type of DNA marker predicts poor outcomes in multiple myeloma, researchers at Winship Cancer Institute, Emory University have found. The marker is a kind of rearrangement of chromosomes that is rarely tested for, but may indicate resistance to immunomodulatory drugs such as lenalidomide, which have become standard therapies…

Hip replacement patients can skip hip precautions, study suggests

Low-risk patients undergoing a total hip replacement with a posterior approach can skip the standard hip precautions currently recommended for post-surgical recovery, according to a new study conducted at Hospital for Special Surgery (HSS), in New York City. Eliminating standard precautions in this population did not increase the risk of…

Newly discovered leukodystrophy in children: Potential cure: The gene that causes the disease is called DEGS1 and its defect may be counteracted with fingolimod

The Neurometabolic Diseases research team at IDIBELL and CIBER of Rare Diseases (CIBERER), led by ICREA Professor Aurora Pujol, has uncovered a novel disease of children affecting the brain white matter -the myelin sheath-, leading to severe incapacity and death in some cases. The gene causing the disorder is called…

A boundary dance of amyloid-beta stepping into dementia: Formation mechanism of the causative substances of Alzheimer’s disease revealed by molecular dynamics simulations and NMR experiments

Many proteins aggregate at higher concentrations and form spherical substances called oligomers and acicular substances called amyloid fibrils. These protein aggregates cause more than 30 kinds of diseases, for example, Alzheimer’s disease is thought to be caused by the oligomers and amyloid fibrils formed by aggregation of amyloid-β (Aβ) peptides….