Safety evaluation of conditionally immortalized cells for renal replacement therapy

A research team assessed the safety of conditionally immortalized proximal tubule epithelial cells for bioartificial kidney application, by using in vitro assays and athymic nude rats. They demonstrate that these cells do not possess key properties of oncogenically transformed cells, including anchorage-independent growth, lack of contact inhibition and apoptosis-resistance. Taken…

Phage therapy shows promise for alcoholic liver disease

Bacteriophages (phages) are viruses that specifically destroy bacteria. In the early 20th century, researchers experimented with phages as a potential method for treating bacterial infections. But then antibiotics emerged and phages fell out of favor. With the rise of antibiotic-resistant infections, however, researchers have renewed their interest in phage therapy….

CAR T-cell therapy may be harnessed to treat heart disease

CAR T-cell therapy, a rapidly emerging form of immunotherapy using patients’ own cells to treat certain types of cancers, may be a viable treatment option for another life-threatening condition: heart disease. In a first-of-its-kind study, published today in Nature, researchers at Penn Medicine used genetically modified T cells to target…

The merits of physical therapy

(HealthDay)—You suffered an injury that has sidelined you from exercise, but you dodged a bullet—your doctor has said that you don’t need surgery. Instead, he or she prescribes physical therapy, most likely to start after a rest period to give any inflammation time to subside. At that point, you’re probably…