Coronavirus: Less people with antibodies than predicted Naturopathy naturopathy specialist portal

Corona: immunization grade lower than thought

Worldwide research by the end in connection with the novel Coronavirus SARS-CoV-2 antibody studies. The results should help to shed light on the course of disease and immunity. A study from Germany shows well: The Immunization is significantly lower than expected.

The Federal centre for health education (BZgA), according to experts believe, that convalescent patients have only a low risk of developing cancer a second Time to COVID-19. Scientific studies have shown that people develop after previous infection-specific antibodies (the body’s own defensive substances) against the Coronavirus SARS-CoV-2, which can neutralize the Virus in laboratory tests. But, apparently, are only a few people detectable antibody.

Information on the current status of Immunity

The Medical faculty of the Technical University of Dresden (TU Dresden) and the Dresden University hospital Carl Gustav Carus launched in may of 2020, a study on the spread of the SARS-CoV-2-Virus-Saxon schools. In a recent communication, the results of the first phase of testing with over 2,000 Participants have been published.

According to the figures, it is the so far largest study in the framework of the re-opening of the schools after the Lockdown is to be recorded, how many students and teachers, antibodies against the SARS-CoV-2 Virus you carry, and how its spread may change over time.

The Numbers give information about the current status of Immunity of teachers and students. They provide therefore important clues for how the school can go after the summer holiday.

Anti body only a few demonstrated

Of the 2.045 examined blood samples for antibodies against the Coronavirus SARS-CoV-2 were only in 12 of doubt, prove. Thus, the Immunization rate is in the group of study participants with significantly less than one percent (0.6 percent) and is lower than forecast.

Dynamics of the virus spread is overestimated

The researchers led by study leader Prof. Reinhard Berner, clinic Director of the clinic and polyclinic for child and youth medicine of the University hospital Carl Gustav Carus, draw relating to a positive conclusion, the dynamic spread of the Virus in families. This appears to have been overestimated in the past. Because in 24 families of the study participants, there was at least a confirmed Corona case, however, only one of the subjects, antibodies were detected.

Schools were not part of the Hotspot

According to the communication, there were in three of the studied schools confirmed Corona cases. Nevertheless, not far more likely to be detectable antibody, which suggests that the schools have not developed to Hotspots.the teachers and students of the institutions concerned

Doctors of the Dresden University hospital Carl Gustav Carus, have been investigated in the months of may and June, a total of 2.045 blood samples from students and teachers from 13 secondary schools in Dresden and the districts of Bautzen or Görlitz.

Of these samples, 1.541 were from students primarily from grades eight to eleven. In addition, a total of 504 teachers have participated, their ages ranged from 30 to 66 years. In the case of students, the proportion of male and female study participants was approximately equal, in the case of the teachers, the teachers dominated with a share of 70 percent.

Hardly silent, symptom-free infections

According to the history, five part of the study gave participants to be previously positive for the SARS-CoV-2 Virus have been tested. In addition, there were 24 households, in which, in the run-up to a family member tested positive had been.

Doctors of the University hospital of Dresden have taken from the subjects and subjects in each five milliliters of blood from the arm. “All the samples were subjected to a single, approved antibody test. He is a machine suitable and identified in the Serum antibodies to the Spike Protein of the SARS-CoV2-Virus,“ explains the Director of the Institute for Virology of the Medical faculty of the TU Dresden, Professor Alexander Dalpke.

In twelve of the 2.045 samples could be detected at the Institute for Virology of doubt, free of antibodies. In five of the twelve cases, there was a well-known proven Coronavirus infection, in seven cases the infection was not known in advance. The dark point for the infection is among the study participants, just over two.

“We go in the summer vacation of 2020, with a status of Immunity, which is not different from the in March 2020. Of the more than 2000 examined the blood samples were only in 12 cases, antibodies were detected, which corresponds to a share of well under one percent. This means that a silent, symptom has been free of infection in the studied by us students and teachers, yet rare, as we had suspected,“ concluded Prof. Reinhard Berner.

Infections before the Lockdown known

It is also striking that in the 24 households in which at least one Corona-the case was known, apparently, only a single infection has taken place, according to the corresponding antibody can be detected.

“These findings provide evidence that the virus transmission in families is not happening as fast as previously thought. More than 20 of the subjects examined, there was at least a proven Corona case in the family; however, were only found in a single of these study participants antibody, which would mean that the largest part of the school children, in spite of the infection if the budget itself is not a infection through. Also this finding you have to think about if to decide on the measures of the contact restriction is new,“ says Prof. Berner.

The information that pupils were used for the study mainly from the eighth to the eleventh day of classes selected because they are moving to a greater degree, regardless of their parents ‘ house, and perhaps also by the requirements of the General disposal, you have also. acceptable, a correspondingly large number of social contacts In addition, were selected for the study schools, one of which is known was that there before the Lockdown SARS-CoV2-infections were detected.

“Here we could notice with pleasure that in the selected age group in the surveyed schools either before the Lockdown even after the re-opening of the Hotspots have developed. Four of the five students, 80 percent, indicated on your class and the immediate family, regular social contacts. Also, this has apparently led to a further spread of the Virus,“ explains Prof. Berner.

A positive antibody test is not a free letter

The second major series of tests in the 13 schools is planned at the beginning of the new school year, a third will be in dependence on the infection to happen by the end of 2020 or early 2021, says Professor Reinhard Berner. He supervised, together with Dr. Jakob Armann the study, while Prof. Dalpke is responsible for samples at the Institute for Virology, the evaluation of the blood.

Together, the scientists warned, to see a positive antibody test as a free letter, for the detection of antibodies does not necessarily mean protection. “In addition, there are for each Test, so-called false positive findings, the supposed anti-body advertisements which are not actually present. We have subjected, therefore, positive results from two other tests,“ explains Prof. Dalpke.

Only the one who was in two of the three tests positive, has also been classified as an antibody carrier. It is crucial, therefore, according to the virologists, the anti-body development in the course. (ad)

Authors and source of information