Medial prefrontal cortex regions involved when the brain decides whether to continue a behavior

A team of researchers affiliated with multiple institutions in France has learned more about the parts of the medial prefrontal cortex (mPFC) that are involved when the brain is deciding whether to continue with a certain behavior or to go with something new. In their paper published in the journal Science, the group describes their study of the brains of epileptic patients and what they learned from them. Saurabh Steixner-Kumar and Jan Gläscher with University Medical Center Hamburg-Eppendorf have published a Perspective piece in the same journal issue outlining the work by the team.

Prior research has shown that one of the more difficult decisions for animals, including humans, occurs in unstable environments when a course change is required. When conditions are stable, most animals and humans pursue the activities that provide the most benefit. But when conditions are unstable, sometimes a given behavior must change, quite often right away. If a rabbit is running from a fox and is losing ground, at some point, it will decide to freeze in place against a backdrop where it hopes to blend in. Prior research has suggested that such nearly instantaneous decision making occurs in the medial prefrontal cortex. In this new effort, the researchers sought to learn which parts of the mPFC carry out the functions involved in such decision making.

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