B cell activating anti-CD73 antibody for the immunotherapy of COVID-19

Despite the advent of numerous vaccines and the discovery of passive monoclonal antibodies for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), there remains an urgent need for definitive therapies for coronavirus disease-2019 (COVID-19) patients. Present global challenges in combatting the pandemic include – the emergence of viral variants; declining immunity following…

Combining antibody markers to improve serosurveillance for SARS-CoV-2

Seroepidemiological studies can provide accurate insights into viral infection fatality rates and the degree of transmission in different populations. Such studies also provide an insight into disparities in infection rates without health-seeking behavior biases. Serosurveillance data is useful in estimating the burden of disease and amplitude of population immunity. Study:…

Monoclonal antibody prevents HIV infection in monkeys, study finds

An experimental, lab-made antibody can completely prevent nonhuman primates from being infected with the monkey form of HIV, new research published in Nature Communications shows. The results will inform a future human clinical trial evaluating leronlimab as a potential pre-exposure prophylaxis, or PrEP, therapy to prevent human infection from the…