How pancreatic cancer cells dodge drug treatments

Cancer cells can become resistant to treatments through adaptation, making them notoriously tricky to defeat and highly lethal. Cold Spring Harbor Laboratory (CSHL) Cancer Center Director David Tuveson and his team investigated the basis of “adaptive resistance” common to pancreatic cancer. They discovered one of the backups to which these…

Treatment Options for Sickle Cell Disease

Routine treatments for sickle cell disease (SCD) are currently limited to blood, stem cell, and bone marrow transplants though other treatment and management strategies are available to help manage anemia and painful episodes amongst other complications with even more promising drugs and treatments being developed currently and in the near…

Pinpointing how cancer cells turn aggressive

It’s often cancer’s spread, not the original tumor, that poses the disease’s most deadly risk. “And yet metastasis is one of the most poorly understood aspects of cancer biology,” says Kamen Simeonov, an M.D.-Ph.D. student at the University of Pennsylvania Perelman School of Medicine. In a new study, a team…

Deficient immune cells implicated in TB disease progression

Nearly a quarter of the world’s population is estimated to be infected with Mycobacterium tuberculosis (M.tb), the pathogen that causes tuberculosis, but less than 15 percent of infected individuals develop the disease. A study published May 24 in Nature Immunology by investigators from Harvard Medical School, Brigham and Women’s Hospital,…

Reactivating aging stem cells in the brain

As people get older, their neural stem cells lose the ability to proliferate and produce new neurons, leading to a decline in memory function. Researchers at the University of Zurich have now discovered a mechanism linked to stem cell aging—and how the production of neurons can be reactivated. The stem…