Treatment Options for Sickle Cell Disease

Routine treatments for sickle cell disease (SCD) are currently limited to blood, stem cell, and bone marrow transplants though other treatment and management strategies are available to help manage anemia and painful episodes amongst other complications with even more promising drugs and treatments being developed currently and in the near…

Pinpointing how cancer cells turn aggressive

It’s often cancer’s spread, not the original tumor, that poses the disease’s most deadly risk. “And yet metastasis is one of the most poorly understood aspects of cancer biology,” says Kamen Simeonov, an M.D.-Ph.D. student at the University of Pennsylvania Perelman School of Medicine. In a new study, a team…

Deficient immune cells implicated in TB disease progression

Nearly a quarter of the world’s population is estimated to be infected with Mycobacterium tuberculosis (M.tb), the pathogen that causes tuberculosis, but less than 15 percent of infected individuals develop the disease. A study published May 24 in Nature Immunology by investigators from Harvard Medical School, Brigham and Women’s Hospital,…

Reactivating aging stem cells in the brain

As people get older, their neural stem cells lose the ability to proliferate and produce new neurons, leading to a decline in memory function. Researchers at the University of Zurich have now discovered a mechanism linked to stem cell aging—and how the production of neurons can be reactivated. The stem…

Targeted elimination of leukemic stem cells

Leukemia is caused by leukemic stem cells which are resistant to most known therapies. Relapses are also due to this resistance. Leukemic stem cells arise from normal blood-forming (hematopoietic) stem cells. Because they are closely related, leukemic and hematopoietic stem cells share many of the same signaling pathways. If the…

Formula predicts ideal dose of stem cells to cure HIV

Scientists have determined the optimal conditions following a stem cell transplant that could control HIV without the need of an everyday pill, according to a study published today in eLife. Finding the right balance of stem cell dose, cell type and timing of antiretroviral therapy (ART) could potentially lead to…

Study reveals surprising variability of muscle cells

Usually, each cell has exactly one nucleus. But the cells of our skeletal muscles are different: These long, fibrous cells have a comparatively large cytoplasm that contains hundreds of nuclei. But up to now, we have known very little about the extent to which the nuclei of a single muscle…