Potential biomarkers of coagulopathy and disease severity in COVID-19

Coagulopathy in coronavirus disease 2019 (COVID-19) displays unusually. Not only do patients display impaired fibrinolysis, but also platelet aggregation, inflammation, and microthrombi. Understanding this pathology could help healthcare workers treat these symptoms, often associated with low survival levels in severe COVID-19 patients. Study: Plasma biomarkers associated with survival and thrombosis…

Inhibition of SARS-CoV-2 helicase by single DNA lesions

The genome of severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 encodes for several non-structural proteins (NSP) involved in viral replication and propagation, with NSP13 known to play a role in RNA unwinding and subsequent transcription of the single-stranded template. Study: Variable inhibition of unwinding rates of DNA catalyzed by the…

Infectious SARS-CoV-2 can be cultured from nasopharyngeal swabs from asymptomatic and symptomatic vaccinated individuals

A team from the National Institute for Infectious Diseases “L. Spallanzani” (INMI) has recently reported their study on 94 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections that occurred after the first or second vaccine dose against SARS-CoV-2 in the Lazio region (Central Italy). Study: Virological and Serological Characterization of…

Efficacy of vaccines against the SARS-CoV-2 Delta variant

The coronavirus 19 (COVID-19), which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first reported in Wuhan, China in late 2019. Since then, COVID-19 has caused the deaths of more than 4.5 million people worldwide, along with social and economic disruption. Study: Prediction of vaccine efficacy…