Reverse transcription-polymerase chain reaction (RT-PCR) has been the gold standard for diagnosis during the COVID-19 pandemic. However, the PCR portion of the test requires bulky, expensive machines and takes about an hour to complete, making it difficult to quickly diagnose someone at a testing site. Now, researchers reporting in ACS…
DNA building blocks regulate inflammation
Mitochondria are the energy suppliers of our body cells. These tiny cell components have their own genetic material, which triggers an inflammatory response when released into the interior of the cell. The reasons for the release are not yet known, but some cardiac and neurodegenerative diseases as well as the…
Individuals with Major Depressive Disorder have accelerated cellular aging
Cells from individuals with Major Depressive Disorder (MDD) were found to have higher than expected rates of methylation at specific sites on their DNA, when compared to cells from healthy individuals without MDD, according to a study by a multidisciplinary team of UC San Francisco scientists, in collaboration with others….
Researchers characterize regions of DNA that impact MECP2 expression
Researchers at Baylor College of Medicine and the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital (NRI) have identified and characterized two regions of DNA required for the proper expression of Mecp2/MECP2 in mice and humans. These findings, published in Genes & Development, are helping to shed…
Scientists determine DNA required for the proper expression of Mecp2/MECP2 in mice and humans
Researchers at Baylor College of Medicine and the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital (NRI) have identified and characterized two regions of DNA required for the proper expression of Mecp2/MECP2 in mice and humans. These findings, published in Genes & Development, are helping to shed…
Study offers new clues to how night shift work increases cancer risk
New clues as to why night shift workers are at increased risk of developing certain types of cancer are presented in a new study conducted at Washington State University Health Sciences Spokane. Published online in the Journal of Pineal Research, the study involved a controlled laboratory experiment that used healthy…
Immune cells in cerebrospinal fluid could be novel biomarkers to immune-based therapies
Results from a study led by Joan Seoane, Director of Preclinical and Translational Research co-program at VHIO and ICREA Professor, show that immune cells accessing cerebrospinal fluid faithfully recapitulate the characteristics of cells identified in brain metastasis, and could therefore constitute novel biomarkers of response to immune-based therapies. Immune checkpoint…
Researchers use functional test to measure the effect of inherited variants in BRCA2 cancer gene
Researchers at Mayo Clinic have combined results from a functional test measuring the effect of inherited variants in the BRCA2 breast and ovarian cancer gene with clinical information from women who received genetic testing to determine the clinical importance of many BRCA2 variants of uncertain significance (VUS). The findings were…
Researchers discover previously-unknown function in enzyme critical for cancer growth
Considered the most lethal form of DNA damage, double-strand breaks must be repaired to prevent cell death. In developing therapies for hard-to-treat breast and ovarian cancers in patients with BRCA gene mutations, scientists aim to identify ways to keep cancer cells from using DNA break repair pathways. New findings demonstrate…
Rekovelle follitropin delta (rhu)
NOTICE: This Consumer Medicine Information (CMI) is intended for persons living in Australia. REKOVELLE® (FOLLITROPIN DELTA) SOLUTION FOR INJECTION Solution for injection in a pre-filled pen follitropin delta (rhu) Consumer Medicine Information What is in this leaflet This leaflet answers some common questions about REKOVELLE. It does not contain all…
Still too soon to try altering human embryo DNA, panel says
It’s still too soon to try to make genetically edited babies because the science isn’t advanced enough to ensure safety, says an international panel of experts who also mapped a pathway for any countries that want to consider it. Mainstream scientists condemned his experiment as unethical, and He was sentenced…