New potential approach to treat atopic dermatitis

How does the immune system respond to fungi on our skin? Researchers at the University of Zurich have demonstrated that the same immune cells that protect us against skin fungi also encourage the inflammatory symptoms of atopic dermatitis. An antibody therapy could alleviate this chronic inflammatory skin disease. The skin…

Fluconazole makes fungi sexually active

The yeast Candida albicans occurs in most healthy people as a harmless colonizer in the digestive tract. However, it can also cause life-threatening infections, especially in immunocompromised patients. These infections are usually treated with the drug fluconazole, which inhibits the synthesis of ergosterol in Candida. Ergosterol fulfils similar important functions…

What happens when sand fleas burrow in your skin?

Tungiasis, a tropical disease associated with poverty, is caused by the penetration of female sand fleas into a person’s skin, usually in their toes or feet. This week in PLOS Neglected Tropical Diseases, researchers report five cases of severe tungiasis to illustrate how the disease may develop into a life-threatening…