Resistance can spread even without the use of antibiotics

Antibiotic resistance does not spread only where and when antibiotics are used in large quantities, researchers conclude from laboratory experiments. Reducing antibiotic use alone is therefore not sufficient to curtail resistance, and should be done in conjunction with measures to prevent infection with resistant germs. Bacteria are becoming increasingly resistant…

Novel combination of drugs may overcome drug-resistant cancer cells

Cancer cells can adapt and develop resistance to chemotherapy drugs, making it difficult to eradicate tumors. A new study led by investigators from Brigham and Women’s Hospital suggests that a combination of three drugs, including a new class of glucose-6-phosphate dehydrogenase inhibitors, could overcome cross-therapy resistance. The results of the…

Fluconazole makes fungi sexually active

The yeast Candida albicans occurs in most healthy people as a harmless colonizer in the digestive tract. However, it can also cause life-threatening infections, especially in immunocompromised patients. These infections are usually treated with the drug fluconazole, which inhibits the synthesis of ergosterol in Candida. Ergosterol fulfils similar important functions…

AIDS: An approach for targeting HIV reservoirs

Current HIV treatments need to be taken for life by those infected as antiretroviral therapy is unable to eliminate viral reservoirs lurking in immune cells. Institut Pasteur scientists have identified the characteristics of CD4 T lymphocytes that are preferentially infected by the virus — it is their metabolic (or energy-producing)…