In the scientific journal Pharmaceutics, researchers from the ESI International Chair of the CEU Cardenal Herrera University (CEU UCH) and ESI Group have just published a new computational topology strategy to identify existing medicines that could be applied to treat COVID-19 without waiting for the research and clinical trial phases…
Researchers identify genes responsible for loss of lung function
Chronic Obstructive Pulmonary Disease (COPD) is a disease caused by cigarette smoking that reduces lung function and causes difficulty breathing. It is the third leading cause of death worldwide. Current treatments for COPD only affect symptoms, not progression. Identifying who is going to get COPD before they get it is…
RNA scientists identify many genes involved in neuron development
Neurons result from a highly complex and unique series of cell divisions. For example, in fruit flies, the process starts with stem cells that divide into mother cells (progenitor cells), that then divide into precursor cells that eventually become neurons. A team of the University of Michigan (U-M), spearheaded by…
Researchers identify ‘instigator’ gene associated with Alzheimer’s disease
In a new paper published in Nature Communications, Mayo Clinic researchers and collaborators report the protein-coding gene SERPINA5 may worsen tau protein tangles, which are characteristic of Alzheimer’s disease, and advance disease. By combining clinical expertise, brain tissue samples, pathology expertise and artificial intelligence, the team clarified and validated the…
Mathematical method builds synthetic hearts to identify how heart shape could be linked to disease
Researchers from King’s College London have created 3D replicas of full-sized healthy adult hearts from Computed Tomography (CT) images and analyzed how cardiac shape relates to function. Published today in PLOS Computational Biology, the study also includes 1000 new synthetic hearts that have been made open access allowing researchers to…
Small cell lung cancer: Scientists identify two new approaches for therapy
Using samples of small cell lung tumors, a research team led by biologist Dr. Silvia von Karstedt has discovered two new ways to induce tumor cell death. One of two subsets of tumor cells can be targeted by activating ferroptosis: iron-dependent cell death caused by oxidative stress. In the second…
New machine learning system developed to identify deteriorating patients in hospital
Researchers in Oxford have developed a machine learning algorithm that could significantly improve clinicians’ ability to identify hospitalized patients whose condition is deteriorating to the extent that they need intensive care. The HAVEN system (Hospital-wide Alerting Via Electronic Noticeboard) was developed as part of a collaboration between the University of…
Researchers identify and characterize three molecular subtypes of Alzheimer’s
Researchers at the Icahn School of Medicine at Mount Sinai have identified three major molecular subtypes of Alzheimer’s disease (AD) using data from RNA sequencing. The study advances our understanding of the mechanisms of AD and could pave the way for developing novel, personalized therapeutics. The work was funded by…
Researchers identify a region of the brain as a key source of signals encoding past experiences in the neocortex
The brain encodes information collected by our senses. In order to perceive and interact with the environment, however, these sensory signals must be interpreted in the context of past experiences stored in the brain and the individual’s current aims. A team led by Prof. Dr. Johannes Letzkus, Professor at the…
NIRS-IVUS imaging can help identify high-risk plaques that can lead to adverse outcomes
New data from the PROSPECT II study shows that NIRS-IVUS intracoronary imaging can help identify angiographically non-obstructive lesions with high-risk characteristics for future adverse cardiac outcomes. Findings were reported today at TCT Connect, the 32nd annual scientific symposium of the Cardiovascular Research Foundation (CRF). TCT is the world’s premier educational…
Researchers identify key role of immune cells in brain infection
A new study has detailed the damaging role played by the immune system in a severe brain condition most commonly caused by the cold sore virus. Researchers have identified the specific type of immune cell that induces brain inflammation in herpes simplex virus (HSV) encephalitis. Crucially, they have also determined…