New insights into the control of inflammation

Scientists at The Wistar Institute discovered that Early Growth Response 1 (EGR1), a protein that turns on and off specific genes during blood cell development, inhibits expression of pro-inflammatory genes in macrophages. As part of their function to protect the body against pathogens, macrophages play a major role in initiation,…

How viruses trick us into spending more time socialising

Can viruses change our behaviour? From Covid-19 to colds, the astonishing truth of how infections trick us into spending more time socialising (and spreading germs!) Can viruses such as the one that causes Covid-19 attack our brains and change our behaviour — thereby prolonging an outbreak? That’s the suggestion from…

New insights into a potential target for autoimmune disease

Immune response is a balancing act: Too much can lead to inflammatory or autoimmune disease; too little could lead to a serious infection. Regulatory T cells, or Tregs, are important players in striking this balance, acting as “brakes” on the immune response so it doesn’t go overboard. Consequently, controlling the…