Breaking the ‘stalemate’ in the most common soft tissue sarcoma in children: First randomized clinical trial to show positive results in rhabdomyosarcoma since 1974

A phase 2 clinical trial has found that combining a molecular targeted drug called temsirolimus with chemotherapy shows promise in the treatment of rhabdomyosarcoma, the most common soft tissue sarcoma in childhood. The Children’s Oncology Group trial was led by Leo Mascarenhas, MD, MS, Deputy Director of the Children’s Center…

Novel combination of drugs may overcome drug-resistant cancer cells

Cancer cells can adapt and develop resistance to chemotherapy drugs, making it difficult to eradicate tumors. A new study led by investigators from Brigham and Women’s Hospital suggests that a combination of three drugs, including a new class of glucose-6-phosphate dehydrogenase inhibitors, could overcome cross-therapy resistance. The results of the…

Bone cells suppress cancer metastases

In breast cancer, there are cases of women and men whose cancer returns in their bones 20-30 years after they were treated for their primary disease and thought they were cancer-free. This phenomenon always puzzled Jefferson researcher Karen Bussard, PhD. How is it possible that breast cancer cells from a…

Multiple myeloma: DNA rearrangement may predict poor outcomes

A certain type of DNA marker predicts poor outcomes in multiple myeloma, researchers at Winship Cancer Institute, Emory University have found. The marker is a kind of rearrangement of chromosomes that is rarely tested for, but may indicate resistance to immunomodulatory drugs such as lenalidomide, which have become standard therapies…

Antioxidants protect cells from harmful water contaminant: Findings could lead to treatment that reduces health risks from exposure to hexavalent chromium

Antioxidants such as vitamin C could help reduce harmful effects from hexavalent chromium, according to a new study performed with human cells. The contaminant, which is often produced by industrial processes, was featured in the biographical movie Erin Brockovich. Federal data from nationwide drinking water tests show that the compound…