Study explores potential new class of antidepressants

Researchers at Vanderbilt University Medical Center have taken a major step that could ultimately facilitate development of a new class of antidepressants which may relieve symptoms more rapidly and effectively and with fewer side effects than current medications. Their approach involves increasing the supply of the excitatory neurotransmitter glutamate in…

Studies explore potential benefits and costs of increased treatment to achieve lower blood pressure

Two studies examining the benefits and costs of treating high blood pressure more intensively, by aiming for lower blood pressure measures, will be presented at the American Heart Association’s Scientific Sessions 2019—November 16-18 in Philadelphia. A separate study analyzed the cost effectiveness of incrementally implementing high blood pressure treatment according…

Potential entry points for Huntington’s disease drug discovery

Huntington’s disease (HD) is one of the four major neurodegenerative diseases that have been most extensively studied. The clinical symptoms include uncontrolled dancing-mimicking behavior (chorea), as well as cognitive deficiency and psychiatric abnormalities. Since the biochemical activity of the mutant huntingtin protein (mHTT) that causes the disease is uncharacterized, the…