Surface protein helps tumor cells form clusters

Circulating tumor cells (CTCs) with stem cell features use the adhesive protein ICAM1 to facilitate formation of CTC clusters, which can travel from primary tumors to other organs in the body, according to a Northwestern Medicine study published in Nature Communications. These CTC clusters are a major source of metastases…

Researchers identify new approach to clear toxic Huntingtin protein

Researchers world-wide are focused on clearing the toxic mutant Huntingtin protein that leads to neuronal cell death and systemic dysfunction in Huntington's disease (HD), a devastating, incurable, progressive neurodegenerative genetic disorder. Scientists in the Buck Institute's Ellerby lab have found that the targeting the protein called FK506-binding protein 51 or…

SARS-CoV-2 limits type I and type III IFN protein biogenesis

Viral infection from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a dysregulated immune response, including low amounts of interferon (IFN) protein needed to suppress viral spread in the body. New research led by Roy Parker of the University of Colorado Boulder finds that SARS-CoV-2 prevents the IFN response…

Natural selection and adaptation of SARS-CoV-2 in mammals

Researchers of the Hubei University of Medicine, China, have analyzed several mutations in different variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from mammal species that suggest natural selection and host adaptation are occurring in the virus. A pre-print version of the research paper is available to read in…

Study reports on two cats that caught COVID-19

Our feline friends are also vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, according to new research posted to the preprint server bioRxiv*. The researchers diagnosed two cats living in France with mild symptomatic COVID-19 illness.  The virus was most likely transmitted from their owners. Study: New detection…