Chimeric vaccines may provide universal protection against viruses like SARS-CoV-2

Researchers in the United States have developed “chimeric” vaccines that provided cross-protection against different strains of sarbecovirus in mice, including the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19). Study: Chimeric spike mRNA vaccines protect against sarbecovirus challenge in mice. Image Credit: NIAID Sarbecoviruses…

SARS-CoV-2 proteins are potent suppressors of innate immunity

Most pathogenic viruses, such as the causative agent of the current coronavirus disease 2019 (COVID-19) pandemic, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), affect normal human biology to co-opt cellular metabolism and replicate successfully. One key pathway is the suppression of innate host immunity. A new paper on the…

Study assesses causes of higher COVID-mortality among men

Researchers in the United States, Germany and Uganda have conducted a study showing that the factors responsible for a higher rate of coronavirus disease 2019 (COVID-19) mortality among males are specific to COVID-19 rather than related to men’s shorter life expectancy. Pascal Geldsetzer from Stanford University in California and colleagues…

Inhalable nanobody shows potent anti-SARS-CoV-2 activity in vivo

Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), are being administered worldwide. A successful, safe and targeted therapeutic drug to treat this infection is yet to emerge. Convalescent plasma, repurposed antivirals, neutralizing monoclonal antibodies, and highly selected nanobodies (Nbs) and multivalent…