Promising approach to reducing plaque in arteries

In a new Yale-led study, investigators have revealed previously unknown factors that contribute to the hardening of arteries and plaque growth, which cause heart disease. Their insight is the basis for a promising therapeutic approach to halt and potentially reverse plaque buildup and the progression of disease, the researchers said….

Certain metabolites linked to stem cell function in the intestine: Molecules called ketone bodies may improve stem cells’ ability to regenerate new intestinal tissue

MIT biologists have discovered an unexpected effect of a ketogenic, or fat-rich, diet: They showed that high levels of ketone bodies, molecules produced by the breakdown of fat, help the intestine to maintain a large pool of adult stem cells, which are crucial for keeping the intestinal lining healthy. The…

New tool for understanding cells in health and disease: A first-of-its-kind data analysis platform is helping make sense of the overwhelming amounts of data generated by single-cell research

A first-of-its-kind data analysis platform is enabling researchers to select the best tool for interpreting the overwhelming amounts of data generated by single-cell research. Accurately making sense of this information will help to explain the vital and varied roles cells play in health and disease. The platform, CellBench, was published…

How egg cells choose their best powerhouses to pass on

Developing egg cells conduct tests to select the healthiest of their energy-making machines to be passed to the next generation. A new study in fruit flies, published online May 15 in Nature, shows how the testing is done. The work focuses on mitochondria, the cellular machines that turn the sugars,…

Pericytes may improve muscle recovery: Pericyte transplantation may improve skeletal muscle recovery following limb immobilization, animal study shows

Extended periods of limb immobilization — whether from long-term bed rest, casting, spaceflight, or other circumstances — can reduce skeletal muscle mass and strength to the extent that recovery is delayed or never achieved. The biological basis for this lack of recovery, however, remains unclear. An animal study published in…

Immune system’s unknown messenger

Researchers can now explain how a cell that is being attacked by bacteria or viruses specifically manages to ‘sound the alarm’ among its neighbouring cells so they can react with a quick response. “We’ve succeeded in finding and describing a messenger which both quickly and effectively can inform the surrounding…