A newly developed immunotherapy that simultaneously uses modified immune-fighting cells to home in on and attack two antigens, or foreign substances, on cancer cells was highly effective in mice implanted with human neuroblastoma tissue, report researchers from the UNC Lineberger Comprehensive Cancer Center and the UNC School of Medicine. The…
Radioligand therapy slows advanced PSMA+ prostate cancer
(HealthDay)—Lutetium-177 (177Lu)-prostate-specific membrane antigen (PSMA)-617 radioligand therapy added to standard care is beneficial for patients with advanced PSMA-positive metastatic castration-resistant prostate cancer, according to a study published online June 23 in the New England Journal of Medicine. Oliver Sartor, M.D., from Tulane University in New Orleans, and colleagues conducted an…
Triple combination therapy shows promise against a rare, deadly asbestos cancer
Combining immune-boosting drugs with radiation and surgery increased the survival and anticancer immune response in mouse models of mesothelioma in preclinical research by Princess Margaret Cancer Centre researchers. In a series of exciting experiments using mouse models of mesothelioma cancer, researchers found that combining two immunotherapy drugs can amplify the…
Small cell lung cancer: Scientists identify two new approaches for therapy
Using samples of small cell lung tumors, a research team led by biologist Dr. Silvia von Karstedt has discovered two new ways to induce tumor cell death. One of two subsets of tumor cells can be targeted by activating ferroptosis: iron-dependent cell death caused by oxidative stress. In the second…
CAR T-cell therapy generates lasting remissions in patients with multiple myeloma
In a major advance in the treatment of multiple myeloma, a CAR T-cell therapy has generated deep, sustained remissions in patients who had relapsed from several previous therapies, an international clinical trial has found. In a study posted online today by the New England Journal of Medicine, trial leaders report…
Depressed and out of work? Therapy may help you find a job
If depression is making it more difficult for some unemployed people to land a job, one type of therapy may help, research suggests. In a new study, 41% of unemployed or underemployed people undergoing cognitive behavioral therapy (CBT) found a new job or went from part- to full-time work by…
Enhanced oral uptake of exosomes opens cell therapy alternative
Cell-derived exosomes are effective in treating disease when mixed with the dominant protein in breast milk and given orally, a new Smidt Heart Institute study of laboratory mice shows. The findings, published in the peer-reviewed Journal of Extracellular Vesicles, could help develop new oral medications for treating patients with muscular…
Hope for children with rare heart condition: Novel stem cell therapy to save the day
Dilated cardiomyopathy (DCM) is a condition caused by the weakening of the heart muscle, affecting the ventricles (chambers in the heart that push blood around the body as it contracts). If allowed to progress unchecked, DCM can lead to heart failure and death, especially in children. The only cure, at…
Fatty liver: the First drug therapy discovered – Naturopathy naturopathy specialist portal
Fatty liver disease treatable? Fatty liver is the most common disease of the liver. Around one in four adults in Germany suffers – sometimes without even knowing it. Because the liver disease caused long as there are no direct complaints. Despite the high prevalence in the population, there is no…
Safety evaluation of conditionally immortalized cells for renal replacement therapy
A research team assessed the safety of conditionally immortalized proximal tubule epithelial cells for bioartificial kidney application, by using in vitro assays and athymic nude rats. They demonstrate that these cells do not possess key properties of oncogenically transformed cells, including anchorage-independent growth, lack of contact inhibition and apoptosis-resistance. Taken…
One-two punch drug combination offers hope for pancreatic cancer therapy
Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified a combination of two anti-cancer compounds that shrank pancreatic tumors in mice—supporting the immediate evaluation of the drugs in a clinical trial. U.S. Food and Drug Administration (FDA)-approved versions of the compounds are used today to treat certain leukemias and…