Surface protein helps tumor cells form clusters

Circulating tumor cells (CTCs) with stem cell features use the adhesive protein ICAM1 to facilitate formation of CTC clusters, which can travel from primary tumors to other organs in the body, according to a Northwestern Medicine study published in Nature Communications. These CTC clusters are a major source of metastases…

IBD Associated With High-Grade Cervical Neoplasia in Women

(Reuters Health) – Women with inflammatory bowel disease are more likely to develop high-grade cervical neoplasia as well as persistent or recurrent cervical neoplasia, a Dutch study suggests. Researchers examined cervical cytology and histology data for 2,098 women with IBD and 8,379 women in a matched cohort from the general…

Quick MRI Scan for Routine Prostate Cancer Screening?

Could imaging be used for routine screening for prostate cancer in healthy men — similar to mammography for breast cancer screening? A quick scan — with 15-minute, contrast-free MRI — detected more clinically significant prostate tumors than the usual screening with a blood test for prostate specific antigen (PSA) in…

Rare Variants of Dermatofibrosarcoma Protuberans (DFSP)

Dermatofibrosarcoma protuberans (DFSP), a very rare tumor that arises in the skin, has significant local invasive potential, and tends to recur locally after surgical treatment. Metastasis occurs in only about 5 percent of cases. DFSP occurs in only 1 in 100,000 to 1 million individuals. Black individuals have almost twice…